1122 Horizontal Aquisition of Murine Akr
نویسندگان
چکیده
From the Laboratory of Viral Carcinogenesis, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21701; the Upstate Medical Center, State University of New York, Syracuse, New York; the Barbara Kopp Research Center, Auburn, New York 13021; the DNA Recombinant Research Unit, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20205; and the Department of Veterinary Pathology, Texas A & M University, College Station, Texas 77843
منابع مشابه
Evidence for the horizontal acquisition of murine AKR virogenes by recent horizontal infection of the germ line
Several recent reports (8, 10, 11, 13) have established the biological and molecular genetic similarity between the endogenous AKV virus of strain AKR, and an N-ecotropic endogenous virus found in the genome of feral Japanese mice, Mus musculus molossinus. The similarities are so striking as to suggest a common origin of these viruses, which are present in some, but not all, inbred mouse strain...
متن کاملThe humoral immune response of NIH Swiss and SWR/J mice to vaccination with formalinized AKR or Gross murine leukemia virus.
The humoral immune responses of NIH Swiss and SWR/J mice immunized with formalin-inactivated AKR or Gross murine leukemia virus, respectively, were examined. Both immune sera had high titers of antibodies detectable in radioimmune precipitation assays using [3H]leucine-labeled AKR virus and in radioimmunoassays using purified virion components. The predominant antibody titers were directed agai...
متن کاملInfectious murine leukemia virus from DNA of virus-negative AKR mouse embryo cells.
DNA from virus-negative AKR mouse embryo cells is infectious for NIH 3T3 cells if the transfected cells are treated with 5-iododeoxyuridine (IdUrd) either before or after addition of the DNA. The virus isolated after transfection of the AKR DNA is an ecotropic murine leukemia virus (MuLV) indistinguishable from endogenous AKR MuLV. The AKR DNA is not infectious in the absence of IdUrd treatment...
متن کاملLymphomagenicity of recombinant mink cell focus-inducing murine leukemia viruses
Recombinant mink cell focus-inducing (MCF) murine leukemic viruses, as well as ecotropic and xenotropic viruses, were tested for ability to accelerate or cause development of lymphoma in AKR and other strains of mice. Of the three classes of virus isolated from AKR, only the MCF viruses were able to accelerate development of AKR lymphoma. This fully supports the idea that the MCF viruses are th...
متن کاملHeteroduplex analysis of the sequence relations between the RNAs of mink cell focus-inducing and murine leukemia viruses.
The sequence relationships betwen AKR ecotropic virus and an AKR-derived "mink cell focus-inducing" (MCF) isolate (AKR MCF 247), between Moloney murine leukemia virus (M-MLV) and an M-MLV MCF isolate (M-MLV83), and between AKR and M-MLV were studied by electron microscopic heteroduplex analysis. The MCF-specific sequences were found to map from 1.95 kilobases (kb) to 2.75 kb (+/- 0.15 kb) from ...
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تاریخ انتشار 2003